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What’s the world state of SARS-CoV-2 seroprevalence in kids?

In a latest research printed in eClinicalMedicine, researchers carried out a scientific evaluate to evaluate world pediatric extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence.

Research: SARS-CoV-2 seroprevalence in kids worldwide: A scientific evaluate and meta-analysis. Picture Credit score: Alyona Shu/Shutterstock


Coronavirus illness 2019 (COVID-19) vaccinations have been administered throughout the globe; nonetheless, kids (people aged beneath 19 years within the current research) proceed to be the most important group of unvaccinated people throughout the globe. The emergence of the extremely immune-evasive SARS-CoV-2 Omicron VOC (a variant of concern) and its sub-VOCs has elevated pediatric COVID-19-induced hospitalizations and demanding care necessities in creating and developed nations.

In regards to the research

Within the current research, researchers assessed SARS-CoV-2 seroprevalence amongst kids throughout nations.

Credible worldwide scientific databases resembling Embase, PubMed, Scopus, and Internet of Science, and preprint servers resembling bioRxiv, SSRN, and medRxiv have been looked for systematic opinions on SARS-CoV-2 seroprevalence amongst kids between 1 December 2019, and 10 July 2022. There have been no language restrictions.

Key phrases included ‘2019 novel coronavirus’, ‘COVID-19’, ‘SARS-CoV-2’, ‘antibody’, ‘coronavirus’, ‘serology’, ‘seroprevalence’, ‘pediatric’, ‘scholar’, ‘kids’ and ‘adolescent’. As well as, the preliminary 10 pages of Google Scholar have been searched utilizing the aforementioned search phrases and names of WHO nations. Furthermore, the staff’s display included research’ bibliographies and related literature opinions to acquire extra information. When out there, institutional studies have been additionally reviewed for every nation.

Moreover, from research reporting seropositivity for various isotypes of antibodies, the rely of youngsters with IgG seropositivity was analyzed. The information have been independently evaluated by three completely different investigators. Utilizing random-effects meta-analyses, pooled seroprevalence estimates have been obtained for various WHO (World Well being Group) areas. Associations with SARS-CoV-2 seropositivity and heterogeneity sources have been investigated by subgroup evaluation and meta-regression evaluation.

The staff excluded information documenting SARS-CoV-2 seropositivity amongst grownup people, information not together with systematic opinions or different literature opinions. As well as, information documenting SARS-CoV-2 seroprevalence on the idea of PCR (polymerase chain response) evaluation, radiological assessments, or case studies and/or case collection have been excluded from the evaluation. Diagnostic SARS-CoV-2 research and duplicate research have been additionally excluded.

SARS-CoV-2 serological epidemiology was stratified primarily based on WHO areas (Japanese Mediterranean, Africa, Southeast Asia, Europe, Western Pacific, and America), WHO sub-areas primarily based on COVID-19 mortality; World Financial institution revenue classes, HDI (human improvement index) ranges, world COVID-19 waves, bias dangers; and methodology of COVID-19 analysis.

SARS-CoV-2 detection strategies included LFIA (lateral circulation immunoassays), ELISA (enzyme-linked immunosorbent assays), CLIA (chemiluminescence enzyme immunoassays), IFA (immunofluorescence assays), VNA (virus neutralization assays), LMAS (Luminex multi-antigen serology assays), and LLIS (luciferase-linked immunosorbent assays). Bias dangers have been assessed primarily based on JBI (Joanna Briggs Institute) instruments for seroprevalence, cohort, and cross-sectional analytical research.


In complete, 46,702 information have been recognized initially, together with 43,734 database information, 2703 preprint information, and 265 information from Google Scholar and article bibliographies, of which 45,809 information have been irrelevant or duplicates and have been due to this fact excluded. After reviewing the complete textual content of 893 information, 247 information (234 and 13 articles and institutional studies, respectively), together with 757,075 pediatric people throughout 70 nations, have been thought of for the ultimate evaluation.

Among the many research, low, reasonable, and excessive danger of bias was reported for 148, 112, and 42 information, respectively. Sampling dates for many research have been the tip of 2021 (pre-Omicron or Delta dominance interval). Most datasets (n=144) used ELISA evaluation for SARS-CoV-2 detection, adopted by CLIA (n=97), fast LFIA (n=46), and different strategies, together with VNA, LMAS, LLIS, and IFA (n=15).

Seroprevalence estimates diverse between seven p.c within the preliminary COVID-19 wave and 38% and 57% within the fifth and sixth COVID-19 waves, respectively. The best SARS-CoV-2 seroprevalence charges have been noticed for Southeast Asia (18% to 82%) and Africa (17% to 66%), whereas the charges have been the least for the Western Pacific WHO area (0.01% to 1.0%).

Seroprevalence estimates have been larger for youngsters aged 10 years to 19 years, for youngsters residing in underprivileged nations and areas (low-income and low HDI areas), and for youngsters belonging to minor ethnicities. There have been no statistically important variations in pediatric SARS-CoV-2 seroprevalence by intercourse.

COVID-19 wave on the time of sampling, gross nation-scale per capita revenue, and the research high quality have been the important thing heterogeneity sources. Of the 757,075 kids analyzed, 131,361 kids demonstrated explicit anti-SARS-CoV-2 antibodies. The sensitivity evaluation findings indicated that the research findings have been extremely strong.


General, the research findings demonstrated that by the tip of the yr 2021, throughout Delta VOC dominance, 50.0% to 70.0% of pediatric people worldwide confirmed COVID-19 susceptibility. The findings underscored the necessity for increasing COVID-19 vaccination applications to pediatric and adolescent people, particularly these residing in underprivileged areas and belonging to minor ethnic backgrounds.



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