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Katie: Whats up and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the tip. And I’m right here at this time with my good friend, Naveen, who’s an intensely curious entrepreneur who has been taking over some large, audacious concepts to push humanity ahead. He’s the creator of the award-winning e book “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Categorical, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Sensible, amongst others.
And his present work is in Viome Life Sciences, which was based in 2016 with a mission of constructing sickness elective by predicting and stopping continual illness by way of a deeper understanding of a person’s biology at a molecular stage. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to forestall and reverse continual illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the 12 months, Most Inventive Particular person by Quick Firm, Prime 20 Entrepreneurs, and plenty of extra.
On this episode, we discuss in regards to the human ecosystem and customized optimization of your intestine well being and your total well being. We discuss in regards to the purpose the intestine impacts the complete physique. Why it’s not simply genetics from our mother and father however truly our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome stability begins at delivery and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.
The distinction between DNA and gene expression. How some meals could be good for some individuals and never others, and find out how to know which is finest for you, but additionally, the universally dangerous meals. Why there are some universality dangerous ones however not universally good ones. Why he doesn’t advocate harsh merchandise that kill micro organism within the mouth or within the intestine. The true purpose it’s necessary to chew your meals very well earlier than swallowing, and a lot extra. Lot’s of sensible data on this episode. Additionally, a number of hyperlinks to study extra within the present notes at wellnessmama.fm, so verify these out. However with out additional ado, let’s be part of Naveen Jain. Naveen, welcome again.
Naveen: Nicely, Katie, so good to see you lastly after an extended, very long time.
Katie: I’m so excited we get to have a dialog and get to file it and share it at this time, and we’re gonna discuss so much about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I’d say you’re the one particular person I do know in actual life who has a Moon rock assortment. And so, I’d love so that you can simply speak about this as a result of I believe you’re my solely hobbyist Moon rock collector.
Naveen: Nicely, I believe, Katie, you already know, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a approach of expressing that there’s nothing that’s inconceivable for us to do. Regardless that it’s referred to as “Moonshots” that folks thought was troublesome, if not inconceivable to do and having, you already know, now to have the ability to go to the Moon and to me, the gathering of area rocks truly was simply merely a pastime of in a position to maintain one thing in your hand. That could be even earlier than the delivery of our planet. And it offers you some thought of how fragile we’re that if we don’t care for ourselves, our planet, we as humanity might not survive. As a species, we might not survive.
So, you already know, thought of when somebody says, “I’m actually anxious about our planet,” ask the planet and planet will inform you, “Don’t you are worried about me as a result of we…” Planet will just do superb however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are linked collectively. When one thing exterior us goes flawed, we as inner ecosystem will even be impacted, proper. And that’s coming right down to, you already know, in the event you have a look at what’s above, so under is admittedly what’s exterior the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.
Katie: I really like that you simply mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you already know him as nicely. And I requested him that query. You recognize, your technology’s gonna face so much within the environmental and local weather stuff. And, I raised this query and he goes, “Nicely, mother, you’re truly asking the flawed query as a result of the…”
Naveen: Oh, I like it, I like it.
Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we must be asking how we could be extra synergistic inside an atmosphere that’s greater than us.”
Naveen: That’s the excellent reply. That’s precisely how I’d see it that…you already know, when individuals say, “Aren’t you anxious in regards to the planet?” I say, “That’s not the query you have to be asking.” It’s, “Are we anxious in regards to the human species?” That’s what we must be asking.
Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I’d say not anxious about however working to unravel. My listeners are fairly well being savvy and perceive or not less than have a passing understanding that intestine well being impacts the entire complete physique. However I really feel like this idea is…nicely, we’ve recognized elements of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…because of firms like Viome, now we have many extra tangible instruments to truly perceive and begin to do one thing about that. However to start out broad, form of give us an summary of what we imply by the well being of the intestine impacts the well being of the entire physique.
Naveen: So, nicely, to start with, you already know, let’s simply begin from the start. We as human beings will not be merely a product of the DNA from our mother and pa. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which might be truly expressed in our human physique will not be our personal. They arrive from these microbes which might be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we have a look at the human beings as such when it comes to all of the genes which might be expressed that makes us who we’re, they don’t seem to be people. They’re principally microbial. We’re residing of their world. They don’t reside in our world, proper.
So, once we perceive that, you already know, although you can argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you can argue sometime that possibly they really created us to unfold them round, possibly they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and cozy place to remain. In flip, they feed us the vitamins that our physique wants to truly be wholesome, proper. So, think about from the time a child is born, and I believe that is one thing that most individuals don’t notice, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can’t be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Meaning it’s to create the ecosystem inside us.
Now think about what nature is telling us, that we simply created a offspring and the easiest way to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by way of the delivery canal, that is the primary publicity the infant will get to the entire world of microbiome. It will get…fully inhales the microbiome because the child’s going by way of delivery canal. And sadly, among the moms for apparent causes find yourself getting a C-section. They really…the infants will not be going by way of the identical…they’re uncovered to pores and skin microbiome reasonably by way of the delivery canal, the microbiome that they’d get by way of the delivery canal. And that could be a essentially…the infant, when it’s born, is definitely…the character has created in a approach that the microbes get launched into the infant on the time of the delivery and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.
And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I believe that is the elemental half that folks want to grasp. Seventy p.c of our immune system is alongside our intestine lining. The truth is, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a good friend and what’s a foe, proper. So, in some sense, in the event you have a look at the human physique, there’s a tube that goes by way of us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and then you definately begin to have a look at all alongside the traces there’s a large quantity of microbial existence there. They usually in truth are always interacting with our immune system and the immune system is now understanding when there may be truly a pathogen that’s coming by way of the meals or the pathogen that’s coming by way of the surface world, find out how to react to it. And these microbes are the primary sign that tells the immune programs, “This isn’t good. Go do one thing about it, proper.”
And I believe to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I believe as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we reduce our pores and skin or whether or not there may be some kind of pathogen or we get some kind of a illness, it usually is designed to heal itself if our physique is in stability. So, when there are intestine microbial actions and the human host are always in sync and wholesome and our immune system is wholesome, then our physique will truly heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique is just not comfy, you get illness which we name illness.
Katie: Yeah, so many necessary factors you simply mentioned to unpack. And I believe the primary being that we actually are extra bacterial than human and also you…right here you mentioned you’re what you eat nevertheless it goes to date past that. It’s not even you’re what you eat and even you’re what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you simply introduced up the delivery canal factor as a result of I’m a doula and I’ve truly helped in a number of C-section births with feeding the infant, as a result of such as you mentioned, in the event you don’t…the infant is of course meant to seed their intestine by way of the delivery canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which might be in that room, every kind of issues. And we all know that this intestine micro organism at delivery, an increasing number of we study, units you up on your entire life. But in addition, the excellent news is…and I do know that Viome does quite a lot of analysis on this. All is just not misplaced in the event you don’t get an ideal begin. We now have the power to form of get a snapshot and look within the intestine in a very distinctive approach after which optimize to enhance somebody’s well being going ahead.
And in addition, such as you mentioned, the physique’s pure state is well being. It’s not typically that we have to do something drastic. We have to get out of our personal approach and simply take away the issues which might be maintaining the physique from being wholesome or possibly generally give it little further vitamins to assist get there. Speak a little bit bit in regards to the science of Viome and what we’re testing as a result of this expertise didn’t even exist a pair a long time in the past, and now now we have such superb information from this.
Naveen: Nicely, it’s very fascinating is this concept of, you already know…in the event you return and have a look at couple of a long time in the past, it was truly the micro organism and all these organisms had been thought-about as an enemy of the human physique. That’s the minute you see them, your job is to kill them as shortly as potential as a result of they’ll’t probably be there for our good, proper. And as we began to study extra in regards to the human physique, we realized that the majority of those organisms are literally commensal. They’re presupposed to be there they usually in truth…once we feed them issues like, you already know…in olden days, once we had been residing within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the basis and eat it. That’s stuffed with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, truly flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these had been all of the vitamins that our physique wanted.
The truth is, in the event you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, in the event you actually take into consideration all of the issues which might be being executed within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it truly impacts the entire physique together with our mind to coming again to it, Katie, that you simply identified. What occurs in our intestine impacts our temper. So, whether or not it’s a melancholy or nervousness or, you already know, you’ll be able to name them any names you need, you already know, lots of this stuff together with autism is now linked straight into the intestine microbiome. The truth is, they’ve executed now the analysis the place they did merely a microbial transplant referred to as a fecal transplant they usually had been in a position to in truth present that youngsters with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They had been in a position to present whenever you took an individual that has a melancholy a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve executed them in mice they usually’ve executed that in truth in people, and clearly, it was executed by mistake however that’s truly the way it occurred.
The truth is, what’s actually fascinating is habit. They usually’ve proven the identical factor. They took…there have been 17 individuals on the analysis that had been fully hooked on alcohol. And people individuals, they gave them a fecal transplant from individuals who truly had no habit. And these individuals’s habit went away. Now think about that, that our intestine microbiome are controlling our mind when it comes to what to do. That’s what the habit is, proper. And I believe that’s actually phenomenal.
And now what we’re studying is each kind of most cancers…in truth what they’ve now checked out is each single strong tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there may be microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism desirous to survive would ever show a microbial peptide except it’s there to idiot our immune system into considering that is self and protects the tumor towards the immune system attacking, proper?
Now, think about what…one other factor that’s most fascinating I discovered was whenever you do immunotherapy, it really works about one-third of the time. And the individuals the place the immunotherapy doesn’t work, within the 70% of the folks that immunotherapy didn’t work, they merely had been in a position to do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome is just not solely there to maintain us wholesome from all of the ailments at this time we name the completely different names. Coronary heart ailments, it’s coming from our intestine microbes truly producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. The truth is, we are able to now have a look at issues like LDL manufacturing which is a foul ldl cholesterol manufacturing and see how microbial actions and microbial metabolites truly change the LDL manufacturing. You’re in a position to have a look at how…what’s taking place in your intestine, how are we altering the inflammatory markers in our host. So, we’re in a position to measure the intestine exercise and the human host exercise, all their cytokines. So, we’re each interleukins, we’re all the inflammatory markers to see how they’re altering with the intestine microbial exercise.
And so, anyway, the purpose I’m attempting to make is that you simply talked about one thing about these micro organism, and I simply need individuals to know the microorganisms will not be simply micro organism. They’re predominantly micro organism however additionally they include yeast, viruses and even the RNA viruses or fungus or mould. All of this stuff are literally the entire ecosystem and the largest half in truth in the event you observed virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And in the event you have a look at any nature whether or not you’re wanting within the swamp otherwise you’re wanting on the intestine microbiome, in truth there are 10 occasions extra phages than the micro organism alone. And which means these viruses that infect micro organism are modifying the bacterial…the organism, the capabilities of those micro organism that in truth adjustments how these micro organism behave when it comes to what capabilities they’re performing.
So once more, what’s actually fascinating is by what organisms are there, won’t ever inform you what’s going on in your physique. The truth is, their capabilities are what makes the distinction. Meaning what they’re producing can…is admittedly the one factor that issues what these intestine microbes are producing, not who they’re. And I believe, Katie, you in all probability know that quite a lot of the individuals like Akkermansia muciniphila. Among the firms are promoting them as a probiotic with out realizing that Akkermansia could be good for some individuals and actually it’s the primary purpose for inflicting a number of sclerosis, and it has additionally been straight linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one particular person and may do one thing actually dangerous in one other particular person. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally completely different than different particular person’s physique. The identical organism or similar probiotic could be good for somebody and might be dangerous for one more particular person. And that’s the largest studying now we have had within the final six years.
Katie: Yeah, I really like that you simply introduced up the fecal microbiota switch as nicely. I’ve seen among the science on this and… you already know, caveat, this isn’t one thing to try at dwelling nevertheless it’s fairly superb what they’re carrying out in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you’ll be able to accomplish with out having to go to that excessive if you already know what you’re working with. And for the final two years, I’ve been saying, you already know, early on in well being and wellness, I’d discover out data, learn research and be so excited and write about it, and I’ve realized an increasing number of over the past 15 years all the pieces is so customized and so individualized. And so now when individuals ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You recognize, I can inform you what I did nevertheless it’s not gonna work the identical for you. It may be an thought with the start line nevertheless it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very completely different.”
Which is why I really like now an increasing number of entry to those at-home testing whether or not it’s issues like Viome, even now blood testing obtainable at dwelling, genetic testing simply so we are able to have extra data and entry. And I’ve mentioned so many occasions on right here we’re every our personal main healthcare supplier. On the finish of the day, it’s nice to work with docs however we’re every our personal main healthcare supplier. And I really feel like having instruments in our pocket that allow us be simpler at that may actually, actually make a distinction. So, let’s discuss a little bit bit extra in regards to the personalization side of this as a result of I additionally am curious…you already know, I do know you mentioned all the pieces is so completely different. What’s good for one particular person is likely to be not for one more. Are there any issues which might be form of universally dangerous that you simply’re discovering in Viome? Like, I’d put possibly processed vegetable oils on the don’t cross checklist, however I’m curious what you’re seeing within the information.
Naveen: Yeah. So to start with, it’s actually fascinating. I believe you phrased it accurately. There isn’t any such factor as common wholesome meals. And which means there isn’t a such factor that’s good for everybody. Meaning the identical meals could be good for you or dangerous for somebody. Nonetheless, there are some common unhealthy issues which you could know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a kind of unhealthy issues. There isn’t any one who says, “The sugar is nice for me, proper.” In order that’s truly having a fried, you already know, fried meals. So, all fried stuff, it’s simply dangerous for everybody. Consuming quite a lot of sugar, it’s simply dangerous for everybody. Nonetheless, what we discover most fascinating is that analyzing the human physique and analyzing primarily based on what’s going on and what’s dynamically altering in your physique…and I believe quite a lot of the people who find themselves listening to it, I would like individuals to grasp the distinction between a DNA which is static. So when individuals do their DNA check, it tells you what’s inherently there in your physique. It doesn’t inform you what is definitely happening in your physique. Meaning…if, Katie, you enable me, I’m gonna clarify the DNA as a result of I believe to me lots of people get very confused about what DNA is.
So, each a part of our physique is similar DNA. Meaning you have a look at my hair, you have a look at my eyes, you have a look at my tooth, you have a look at my nails, you have a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Identical DNA. And the reply is there’s…when some genes are overexpressed, some genes are underneath expressed, the identical DNA can develop into eye, similar DNA can develop into nail, similar DNA can develop into pores and skin, similar DNA can develop into coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you’re writing is definitely what’s being expressed. It’s referred to as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each potential factor that may occur. And that’s one factor.
So, what we do at Viome, Katie, is we have a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and inform you…some information to share with you in direction of the tip. As soon as we perceive all that’s happening, we’re in a position to then inform you, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is just too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so it is best to reduce it down, proper.”
We are able to inform you that…lots of people will inform you go take vitamin B3. However vitamin B3’s truly not good for you when you may have excessive uric acid manufacturing. So don’t take vitamin B3 you probably have excessive uric acid manufacturing. Equally, everybody will inform you, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t wish to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people assume in some way taking NAD or NR, and NMN which is precursor to NAD is definitely improve your longevity. It’s true for some individuals it could try this, however for others it truly will hurt you when you may have excessive mobile senescence, or when you may have excessive inflammatory exercise. You don’t wish to be taking further NAD as a result of that’s gonna improve the mitochondrial biogenesis that’s going to extend extra free radicals, gonna improve excessive mobile senescence, proper.
So, the concept actually is that it’s important to study what is going on earlier than you deal with your physique like a black field. And I believe you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who have to know what is going on in our physique as a result of our main care physician…I don’t learn about you, Katie. After I go to my main care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the sick, I’ll provide the tablet.” And that’s all they’re merely doing. They don’t have to…they don’t care to grasp what’s inflicting that to occur in my physique. Like, you had Hashimoto, or in the event you had any kind of an autoimmune illness, the very first thing they inform you is simply take the immune suppression medicine and suppress the symptom. Not fear about what’s inflicting it, and that could be a elementary drawback that our healthcare system has is that our medical industrial advanced, everybody makes cash once we are sick and nobody makes cash once we are wholesome. And so, we determined to vary that. In my world of the longer term, Katie, we consider that…I believe similar to you simply mentioned, the way forward for healthcare goes to be delivered at dwelling, not on the hospitals.
And the medicines of the longer term are gonna come from a farm, not a pharmacy. And that’s going to be the largest change you’ll begin to see us taking management of our personal well being. And I believe COVID has been one of many…I’d say in the event you look again at COVID 10 years from now, it is going to be the largest inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.
Katie: Completely. I believe so many good silver linings and educating moments in COVID and folks spent extra time at dwelling and with their households cooking dinner at dwelling. There have been quite a lot of nice outcomes, as onerous because it was for many individuals. I believe we are able to give attention to these positives. And I really like your clarification of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go a little bit bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some large advances since then. So, speak about form of the snapshot of what Viome is testing after which how individuals are making adjustments primarily based on that and what they’re seeing.
Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good nevertheless it didn’t inform us how these intestine adjustments had been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID truly, we launched our well being intelligence check that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t should go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re in a position to now have a look at each your intestine well being and your human host and in a position to now inform you what’s your organic age. And that tells you not solely, you already know, how nicely or how poorly your physique is getting older in comparison with your chronological age.
So, to present you an thought, I’m now gonna be 63 in September and my organic age is right down to 50. And that tells you that actually that my physique is performing on the stage once I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than in truth I had once I was 50. And that merely tells you what your organic age is. Then we provide you with immune well being. Meaning how nicely are you protected towards in the event you had been to catch flu or chilly or any kind of pathogen, how nicely your physique is ready to defend itself? And that’s your immune well being. Your mobile well being. That tells you ways nicely your cells are in a position to endure the issues which might be happening within the human physique. Mitochondrial well being, that’s your vitality manufacturing unit. How nicely the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We provide you with clearly your intestine well being.
And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product referred to as full physique intelligence. And for the primary time, we’re gonna be analyzing all the best way from high of your tube, your saliva, your stool and blood, all three on the similar time. And by that, we’re additionally gonna be capable of present you some further insights equivalent to your coronary heart and metabolic well being. We’re gonna be providing you with your mind and cognitive well being. We’re gonna be capable of present you your oral well being equivalent to your gum well being, your tooth well being and all of the gum, you already know…leaky gum as a substitute of simply leaky intestine. We’ll be capable of present you ways nicely your boundaries of your gums are performing in order that microbes will not be going into your blood.
And different factor we do now which we didn’t do till a couple of yr in the past is whenever you do a check, not solely you get your deep perception what’s taking place in your physique and never simply inform you listed below are the meals which might be good for you and right here is why. Listed below are the meals it is best to keep away from and why. We used to inform you listed below are the dietary supplements it is best to take. Now we transcend that, Katie. We’re in a position to inform you you solely want 22 milligram of berberine every single day. You want 17 milligram of elderberry every single day. You want 79 milligram amylase every single day. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.
There isn’t any premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the best way, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique adjustments, we modify your dietary supplements on the similar time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you actually need is butyrate now,” proper. And we actually are in a position to modify your…as your physique is altering, we adapt the diet that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.
Different issues that I’m actually, actually enthusiastic about…and now we have not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a shopper you’ll be capable of spit in a tube and with 95% specificity and 90% sensitivity, we’ll be capable of inform you you probably have any oral most cancers or throat most cancers. After which we’ll be capable of truly join you with a health care provider to have the ability to do one thing about it. So, if you’re above…over 50 years previous or have any historical past of smoking, vaping, chewing tobacco, you’ll be capable of truly at dwelling do a check and truly know that you simply’re not at a threat of growing a most cancers proper now. Otherwise you’re growing a most cancers proper now.
Katie: Yeah. That is so leading edge and I believe simply to focus on what you mentioned, that is actually fascinating information of mainly machine studying and AI and this adaptive expertise. And since you’ve now examined 1000’s and 1000’s, in all probability tons of of 1000’s of individuals, then the algorithm has entry to all this data so it may possibly proceed to get an increasing number of specialised and direct with the suggestions and study your individual physique over time. So, you’re getting this type of ongoing, correct image which I believe is so fascinating.
Naveen: Yeah. So, Katie, now we have analyzed over 350,000 samples already. And that has given us this…you already know, the a part of being the…a part of that Viome ecosystem is each single one who joins profit from the opposite 350,000 samples that now we have analyzed they usually contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one who joins profit themselves and advantages the humanity on the similar time as a result of now the extra we study, the higher suggestions we are able to make for everybody. So, earlier than we simply solely might have a look at your stool. Now we have a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor will likely be with urine. After which we’re gonna begin to have a look at different biomarkers in your physique. So, our suggestions get an increasing number of exact as we study an increasing number of in regards to the human physique. And our actual hope is, you already know, in my lifetime we’ll be capable of perceive what causes the onset of a continual illness and what causes them to progress and to have the ability to stop them from taking place within the first place, to diagnose them early after they truly do occur, and to provide you with a treatment for these ailments. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the last word aim of our life.
Katie: And I really like that you simply introduced up the interplay of all of the completely different microbiomes throughout the physique as nicely and the way you’re all of those, as a result of a few of my early analysis was in oral well being and studying for example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the similar time. And it’s because now we have an oral microbiome. And if it will get out of stability in a single path or the opposite, you’re gonna find yourself with these issues. However the reply is just not sterilizing your mouth and killing all micro organism similar to we wouldn’t wish to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Identical factor with the intestine. And such as you mentioned, you’re these all through the entire physique. I do know your daughter’s additionally performing some fascinating analysis with the vaginal microbiome and I’m excited to talk along with her about that.
However I believe, like we talked about to start with, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra form of intricate information we are able to get to make enhancements over time and naturally there can be a most cancers connection right here. You recognize, I’ve heard it mentioned that most cancers is a metabolic illness in some half. And this can be a approach of…as a result of even inside a person, in the event you’re a metabolic illness, you’re , “Okay, we have to get blood sugar in verify. We have to get blood stress in verify. We have to get weight problems measures in verify.” However the best way to do this’s gonna be completely different for each single particular person.
Naveen: I believe it’s a metabolic and inflammatory illness. So, I imply, it’s brought about…continual irritation is a root explanation for continual ailments. Nonetheless, what causes the irritation in our physique is completely different for every particular person. So although it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very completely different. And as you talked about, our daughter is, you already know…has this firm referred to as Evvy, E-V-V-Y, which seems on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single lady ought to try this as a result of that’s actually…goes to be…you already know, a number of ladies undergo by way of most of the ailments that we as males would by no means perceive. And that to some extent is, you already know, largely reproductive organ and most of the occasions the later analysis exhibits that vaginal microbiome is concerned in preterm delivery, within the well being of the infant and all of the issues that you simply talked about because the child goes by way of the delivery canal. All of the issues that come out in truth are contributory from the vaginal microbiome. So, my excessive advice…once more, I’m biased. I believe each lady must be doing the Evvy check, proper.
Now, coming again to the belongings you talked about that, you already know, human well being is advanced however as soon as we perceive biochemical stage what’s going on, that’s the explanation as a substitute of organisms and as a substitute of DNA, we centered on the gene expression or RNA. We centered on what microbes are producing. Trying on the entire physique. And I believe, Katie, I wanna level out that the merchandise that you simply construct for oral well being are among the finest merchandise as a result of, to me, what’s the greatest gamechanger is individuals thought the organisms had been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t try this. If you kill the ecosystem in your mouth, it truly destroys the entire digestive tract. And I wanna simply emphasize, you already know, to individuals when our moms advised us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too large to go down our esophagus, proper. It was truly was whenever you chew your meals, you’re permitting the oral microbiome in your saliva to truly predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.
So, the principle factor is that we have to enable the oral microbiome to predigest the feed so your small gut can now take up the vitamins which might be already predigested. So, when you’re…so two issues you might want to take into consideration right here. And one is when you’re confused and you’re consuming your meals, it doesn’t get correctly digested and right here is why. When you’re confused, you’re in a battle or flight response. And the primary factor that occurs whenever you’re in battle or flight response is your digestive system shuts down. Bear in mind why it was designed. If you’re operating away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And in the event you turned lunch for another person, it didn’t matter. And in the event you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you can digest your meals.
If you come from work and you’re confused, what will we inform individuals? Earlier than you eat, do the gratitude. Why is that? It’s since you wish to carry your physique from sympathetic mode into parasympathetic mode. Eliminate battle or flight response. By taking the deep breath, by doing the gratitude, what you’re doing is definitely permitting your physique to have the ability to be able to digest the meals. Then whenever you chew your meals, you’re permitting your saliva and oral microbiome to truly predigest your meals. And these are easy methods we realized within the historical tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you might not know that my mother and pa and our faith, they don’t eat after sundown. And I all the time surprise why would that be. And it seems as a result of you might want to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of individuals will get three, 4 hours of digestion. So, in truth telling that, you already know…and that to me was actually the factor that we realized as a part of our tradition. Really, seems we’re very scientific.
And I wanna come again to the oral merchandise. I believe individuals must be actually desirous about oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you already know, probiotics. And the merchandise, among the merchandise that you’ve, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I believe everybody who’s listening to it to start out concentrate as a result of that’s the primary. Your mouth truly is the start of your digestive tract. It’s not merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.
Katie: I completely agree. I believe very multifaceted however begin with the mouth is so necessary. And I really like a few the belongings you simply talked about about why we don’t digest meals if we’re confused and we all know, after all, that People reside in a continual state of stress typically. And one factor I’ve develop into keen on…you already know, there’s a purpose many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you’ll be able to merely do respiration workout routines. Do some field respiration to calm your nervous system. I really like that your loved ones naturally from a spiritual perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice once I time restricted eat and for a very long time I’d wait and never eat until midday after which eat later within the day. And I observed once I shifted that to consuming and stopping by sundown, I really feel so significantly better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that whenever you’re sleeping, you could be therapeutic and your physique can get into autophagy and you’ll allocate sources to all of the pure processes the physique has inbuilt to maintain us wholesome.
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And I additionally wanna piggyback on what you mentioned about the identical purpose we don’t wanna kill our oral microbiome is identical purpose we don’t wanna kill our intestine micro organism as nicely however I nonetheless see individuals form of hopping on the bandwagon of those actually harsh cleanses or after all individuals generally take antibiotics for causes whether or not they should or not. And people can each have a fairly harsh affect on the intestine. And so, I’d love to speak about it. Possibly if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine concern associated to actually form of killing a few of these good micro organism. Clearly, Viome helps with this however form of, like, what could be executed? How can we assist repair it?
Naveen: So, very first thing is, you already know, earlier than you go begin taking quite a lot of issues is to grasp, what’s the state of your intestine micro organism? So do a Viome check, perceive the place it stands. And then you definately begin to have a look at what you…you already know, we inform you what are the meals it is best to eat. And once more, taking quite a lot of the fermented meals particularly whenever you’re attempting to repopulate or rebootilate your intestine microbiome, actually the issues must be diversification. So as a substitute of simply taking one kind of probiotics, you have to be taking kombucha, the kimchi, the…you already know, all of the fermented meals you’ll be able to probably get your arms on. So, whether or not it’s a yogurt or, you already know, not less than oat milk yogurt in the event you can. I imply, I’m a giant fan that I believe dairy…in truth for lots of the individuals, dairy is the large drawback. Now I’m not saying it’s for everybody however quite a lot of the individuals, dairy might be a giant drawback. And the mammalian merchandise truly might be a giant drawback for some individuals and never for others.
So, I’m not the one that is preaching veganism right here in any respect. What I’m saying is know what is nice for you. There are lots of people who can eat purple meat for all of their life and reside to be 100, and the explanation for that’s purple meat comprises clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the center illness. So, it’s not the purple meat that causes the center illness. It’s the byproduct of how the purple meat is digested in some folks that produce TMA. So, in case your TMA manufacturing is low, it is best to eat purple meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to grasp, don’t merely ban meals and entire class of meals.
One other factor that we realized…we printed a paper having analyzed over 100,000 individuals at the moment on getting older. And what we discovered, Katie, that you could be discover actually fascinating is individuals who had been on these fad diets like, you already know, keto food plan or paleo food plan had been the worst offender of their organic age. The individuals who had been on keto food plan in truth had been three to 5 years older than their chronological age and the identical is true for paleo food plan. It seems that people who find themselves on balanced food plan, which means they had been consuming their carbs however not so much however they had been consuming their regular carbs, they had been consuming their protein, they had been consuming their fats they usually had been consuming the protein, they had been far more balanced, had been truly higher off biologically than reducing out the entire nutrient group fully.
Katie: That is smart, that we’d like the range. And I’ve realized an increasing number of as nicely that I believe the simplistic model all of us realized, hopefully realized at school was about simply form of energy in, energy out. And I’ve heard it mentioned, you already know, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra various and necessary than that.
And what’s subsequent for Viome? I’m curious as a result of I do know you’re always doing analysis right here, and such as you mentioned, your aim is to sort out continual illness in its entirety. So, what’s within the pipeline for you guys?
Naveen: Really, I discussed that subsequent check we’re launching in June is a full physique intelligence. We’re launching a most cancers detect check. And we’re making our dietary supplements and probiotics an increasing number of exact for each particular person since we make it for every particular person. We’re, you already know, attempting to do further assessments now and our aim is to launch within the subsequent six months one other check which is gonna be extra, like, a proteomics check as a result of the issues we can’t see within the blood as a result of they’re produced some other place. So, can we measure issues, you already know, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict you probably have a leaky intestine by LBP, by CRP which truly is completed within the liver? So, we’re going to have the ability to truly measure further issues along with simply those that we’re measuring, and the extra data we are able to study, the higher suggestions we make. So, our hope is to proceed to launch these assessments that give us higher and higher insights and which means we are able to make an increasing number of exact advice for every particular person.
Final aim actually is to grasp…as you say, the human physique is a chemistry lab. We’ve got mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor individuals want to grasp that the gene expression tells you what biochemistry is occurring within the physique. And that’s a purpose…and actually, Viome is the one firm that does have a look at the gene expression as a result of there isn’t a different firm that has this expertise. And I believe individuals who have listened to your earlier podcast, we talked about, this explicit expertise got here out of Los Alamos Nationwide Lab the place they’d the laboratory for biodefense venture. And that’s the explanation nobody else can do it as a result of it took 10 years and multibillion {dollars}’ value of sources to develop this expertise. Sadly, we had been very lucky to have the ability to get the license to have the ability to use this expertise to assist the humanity get higher. And if our mission was merely to earn a living, we’d not have been in a position to license this expertise, proper.
So, the very fact at this time we’re merely centered on making each single particular person be higher. You recognize, our mission on day one was what if we might perceive the human biology at a molecular stage so we are able to stop, diagnose early and treatment these continual ailments together with most cancers and getting older? And I believe quite a lot of the individuals who have heard you and I discuss previously, you already know that I misplaced my dad to most cancers and that was one of many greatest motivator for me as a result of if I had began this firm half a decade earlier than I did, I might have probably saved my dad. And, you already know, having watched him undergo that ache or struggling by way of most cancers I spotted that although I couldn’t save him, I might dedicate my life to saving everybody else. And that will likely be my approach of letting him know that, you already know, I’m so happy with what he…how he raised us as a baby and giving us all the pieces now we have so we’re in a position to save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or melancholy, nervousness or most cancers.
And my hope actually is that in our lifetime we are going to completely eradicate most cancers from the human physique. And if I had been to make a prediction at this time, I’ll inform you inside a decade I believe we are going to do away with most cancers from the human physique.
Katie: That’s a giant declare and I hope we’re on monitor for that as nicely. I’ve misplaced two prolonged relations within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m certain the continual stress of the final couple of years is just not serving to that drawback. So, I’m grateful that there are sources such as you, and I’ve executed Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna be sure that…I do know you’ve supplied a reduction code for the Viome testing. In order that hyperlink will likely be within the present notes for you guys listening at wellnessmama.fm. You could find the low cost code and the hyperlink on to it there. And to verify I respect your time, there’s a pair final questions I’d like to ask you. The primary being if there’s a e book or a lot of books which have profoundly influenced your life. And if that’s the case, what they’re and why?
Naveen: Yeah, so the e book that actually influenced me…there’s a e book by Clayton Christensen, you already know. I really like the person and I noticed him earlier than he died. The e book he wrote, “How Will You Measure Your Life?” And to me it was such a profound e book which tells you that it’s important to be 100% trustworthy. You can’t be 99% trustworthy as a result of as soon as you are taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll all the time be another excuse to make an exception. And so, it’s important to focus your self to by no means, ever compromise in your rules that you simply stand for. And that was simply completely a fabulous e book I learn.
You recognize, the e book that additionally…I imply, clearly I wrote a e book referred to as “Moonshots” that’s actually about making a mindset of abundance reasonably than a mindset of shortage. And the elemental perception that I’ve is that there’s nothing that people will not be able to doing if we truly get our mindset to consider we are able to. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to resolve whether or not they can or they’ll’t. That after you consider one thing is inconceivable, it turns into inconceivable for you and nobody else. And so, you’re fully in management. The one factor you’ll be able to’t do is what you’ll be able to’t think about. Every little thing else is feasible.
Katie: I really like that. I do know you and I each increase our children with that mindset and yours are older and doing superb issues out on the planet already and mine are to start with levels of that. And lastly, what parting recommendation would you want to depart with the viewers at this time? May very well be associated to one thing we’ve talked about or completely unrelated.
Naveen: I’d say dream so large that folks assume you’re loopy. Meaning by no means let somebody inform you which you could’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self is just not about being self-conceited. Loving your self is about not searching for another person’s approval to do the issues that imply so much to you. Observe your coronary heart, observe your intestine, hearken to your intestine and observe what it tells you. Discover a goal in life. When you discover a goal in life, you’ll by no means ever assume it’s work. I rise up every single day at 4 a.m., and that’s my recommendation to everybody. Everytime you rise up within the morning, in the event you’re not leaping out of the mattress, it is best to give up what you’re doing as a result of that’s not your calling, as a result of whenever you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to unravel that drawback.
And, Katie, I simply wish to reiterate, I met your children and I do know I keep in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to truly transfer this humanity ahead. You’re elevating these kids with the mindset that all the pieces they wish to do, they’ll. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it quite a lot of occasions. Like, once we increase our youngsters, we inform them, “Our love for you is unconditional however our approval is just not.” And what which means is just is that we’ll all the time love you, we’ll all the time be there for you, however I’m not gonna inform you I’m happy with you except you do issues that make us happy with you. And that’s actually the factor about telling the kids that their success won’t ever be measured by how a lot cash they’ve within the financial institution. Will probably be measured by what number of lives they enhance. And the humility is an indication of success as a result of in the event you nonetheless have iota of vanity left in you, which means you’re nonetheless attempting to show one thing to your self or another person. And humility tells you not have to do this, proper. And that could be a true signal of success. And all I can say is I’m so happy with each considered one of your kids, Katie. And I can’t anticipate them to develop up and truly do issues that can make our youngsters’s and grandchildren’s life higher.
Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over truly parenting earlier than we ever talked about well being. And we share that similarity. I inform my children every single day, “I really like you unconditionally and there’s nothing you ever should do to earn my love and there’s nothing you can ever do that might take away from my love.” However you’re proper. Additionally, I would like that, like, their pleasure to return from within, like…and I inform them typically, “It’s essential to really feel actually happy with how onerous you labored and you have to…” As a result of I would like them to have that inside them and that self-love.
And because of this I’m so grateful each single day that I get to speak to our viewers that’s listening at this time of mothers, as a result of I believe mothers have such a tremendous distinctive skill to actually shift the way forward for humanity by how we guardian our children and by serving to kind these future leaders. And for individuals who aren’t already aware of you, I’d encourage you to hearken to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your children on their life journeys and your spouse in her personal proper is unimaginable as nicely. So very grateful on your entire household and for all that each one of you’re doing on the planet and on your time at this time. I understand how busy you’re and I’m so grateful you took the time to be right here.
Naveen: Oh, Katie, it’s all the time an honor and a pleasure to be talking with you, and I’m wanting ahead to our subsequent dialog.
Katie: And thanks, as all the time, to all of you for listening and sharing your most dear sources, your time, your vitality, and your consideration with us at this time. We’re each so grateful that you simply did. And I hope that you’ll be part of me once more on the subsequent episode of the “Wellness Mama” podcast.
For those who’re having fun with these interviews, would you please take two minutes to depart a ranking or evaluation on iTunes for me? Doing this helps extra individuals to seek out the podcast, which implies much more mothers and households may benefit from the knowledge. I actually respect your time, and thanks as all the time for listening.