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How Lengthy Does it Take for Cymbalta to Work? — Talkspace

Printed on: 23 Could 2023

How Long Does It Take for Cymbalta to Work

Cymbalta (duloxetine) is an antidepressant treatment used to deal with a number of psychological well being circumstances, together with main depressive dysfunction (MDD) and nervousness. 

Cymbalta is a serotonin noradrenaline reuptake inhibitor (SNRI). SNRIs alter serotonin and norepinephrine ranges within the mind — two hormones linked to temper. It may possibly take time for Cymbalta to succeed in its full impression.

How lengthy it takes for Cymbalta to work varies, however analysis exhibits that, on common, it takes about 2 – 4 weeks to begin working. That stated, it’s not unusual for it to take as much as 6 – 8 weeks earlier than a big change in depressed temper turns into noticeable. 

Preserve studying to be taught extra about how lengthy Cymbalta takes to work — we’re answering all of your questions, so you may make an knowledgeable determination about whether or not or not Cymbalta could also be best for you. 

Can Cymbalta Work Proper Away?

The reply is advanced. Some individuals would possibly discover reduction from signs inside a couple of days, however it might take a number of weeks for others to expertise the total results of Cymbalta. This vary depends upon components resembling age, medical historical past, drug interactions, metabolism, and pre-existing circumstances.

How briskly does Cymbalta work for nervousness?

Questioning how lengthy it takes for Cymbalta to work for nervousness? Sadly, this may additionally fluctuate from individual to individual, so the reply isn’t easy. Typically, it takes 2 – 4 weeks of standard use earlier than Cymbalta’s results on nervousness turn out to be apparent. Nonetheless, some could expertise diminished signs as quickly as the primary week or two.  

A number of components come into play within the timeline of Cymbalta’s effectiveness for nervousness, together with dosage quantity and frequency of administration. The kind of nervousness being handled can even have an effect on how briskly Cymbalta begins working. For instance, when you’re taking it for generalized nervousness dysfunction (GAD), it would take extra time earlier than the consequences are felt in comparison with a panic dysfunction or social phobia.

Psychiatry and Prescriptions On-line

Obtain an analysis and prescription for psychological well being treatment (if wanted) from a psychiatry-trained medical supplier.

How Do You Know When Cymbalta Is Working?

A number of indicators may help decide if Cymbalta is working successfully. One of the vital obvious indicators that Cymbalta is working is decreased signs. You would possibly discover an enchancment in disposition and vitality after taking Cymbalta. 

One other signal Cymbalta is working is when you’re experiencing fewer unwanted side effects than whenever you first began the prescription treatment. Widespread unwanted side effects can embrace nausea, drowsiness, dry mouth, constipation, and Cymbalta weight acquire, which regularly resolve in time.  

“Usually, the particular person will see an enchancment in urge for food, sleep, and vitality inside the first 2 weeks. Though there might not be a visual enchancment within the depressive temper immediately, it begins after weeks 6 – 8. There are fewer indicators of unhappiness, crying spells, or irritability, and it’s simpler to finish your actions of day by day life resembling consuming, sleeping, and primary hygiene.”

Talkspace therapist Cynthia Catchings, LCSW-S

Components that Have an effect on the Onset of Cymbalta’s Results

The speed of onset for Cymbalta’s results hinges on a number of issues. For those who’re contemplating taking this prescription treatment, it’s necessary to know these components to know whenever you would possibly anticipate outcomes.

  • Dosage: The dosage of any treatment can have an effect on how rapidly it takes impact. Solely a healthcare supplier can present correct medical recommendation and decide the right dosage on your situation, signs, wants, and life-style.
  • Frequency: How typically you’re taking Cymbalta may also have an effect on how rapidly it begins working within the physique. Constant dosing as directed by a medical skilled is crucial for reaching optimum outcomes and mitigating potential dangers.
  • Physique weight: Physique weight can play a job in how briskly you would possibly really feel reduction from signs after beginning Cymbalta. Individuals who weigh much less would possibly really feel reduction extra rapidly attributable to variations in metabolism.
  • Age: Some analysis means that age would possibly have an effect on how rapidly your physique chemistry adjusts to Cymbalta use. Youthful individuals would possibly expertise fewer unwanted side effects of Cymbalta and see sooner outcomes. Moreover, adjustments like menopause or hormonal imbalances related to growing old would possibly alter the response fee to Cymbalta use.  

“Not taking Cymbalta as prescribed or stopping remedy can have an effect on the onset of its results. Headache, nausea, fatigue, and sexual unwanted side effects, amongst different points, can forestall you from taking it as prescribed. That may have an effect on the onset, not permitting you to learn from it absolutely. Some meals and medicines can even forestall Cymbalta from working as anticipated. It’s necessary to speak to your medical skilled about do’s and don’ts whereas taking it.”

Talkspace therapist Cynthia Catchings, LCSW-S

What to Do When Cymbalta is Not Working

When Cymbalta isn’t working, it may be irritating. Fortuitously, there are some issues you are able to do when you’re not getting the outcomes you hoped for.

  1. Speak to your healthcare supplier:They could alter your dosage, offer you medical recommendation and suggest making an attempt a unique drug, or counsel life-style adjustments to assist enhance your signs.  
  2. Modify your dosage: Adjusting the treatment dosage till you discover the best quantity is frequent. Don’t alter your dosage with out prescribed directions out of your physician.
  3. Look into various remedy choices: Exploring different remedy choices like bodily exercise and self-care practices resembling meditation, yoga, and diet alterations would possibly assist scale back melancholy and nervousness with out solely relying on prescription drugs. Common breaks all through the day or partaking in actions that deliver pleasure into your life may help scale back stress ranges.

Get Customized Psychological Well being Remedy with Talkspace

For those who really feel such as you’ve tried all the things however nonetheless haven’t been profitable, it could be time to hunt common assist from a psychological well being specialist. The proper psychiatrist can consider why your antidepressant treatment isn’t working for you and create an individualized remedy plan tailor-made to your particular wants.  

Talkspace is an on-line psychiatry and remedy platform the place customers have handy entry to telehealth. All conversations are personal and safe whereas providing customized help and suggestions from licensed therapists and psychiatrists at inexpensive costs in comparison with conventional workplace visits — making it simpler than ever to get high quality psychological healthcare with out leaving house. Attain out to Talkspace to be taught extra about how we may help you. 


  1. Duloxetine (Cymbalta). NAMI. being-Drugs/Sorts-of-Treatment/Duloxetine-(Cymbalta). Accessed March 7, 2023. 
  2. Skinner MH, Kuan H-Y, Skerjanec A, et al. Impact of age on the pharmacokinetics of Duloxetine in girls. British Journal of Scientific Pharmacology. 2003;57(1):54-61. doi:10.1046/j.1365-2125.2003.01963. Accessed March 7, 2023.

Talkspace articles are written by skilled psychological health-wellness contributors; they’re grounded in scientific analysis and evidence-based practices. Articles are extensively reviewed by our staff of medical specialists (therapists and psychiatrists of varied specialties) to make sure content material is correct and on par with present trade requirements.

Our objective at Talkspace is to supply probably the most up-to-date, beneficial, and goal info on psychological health-related matters so as to assist readers make knowledgeable choices.

Articles comprise trusted third-party sources which can be both immediately linked to within the textual content or listed on the backside to take readers on to the supply.

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